Transcription profiling of human pleural mesotheliomas

ABSTRACT: The goal of our study was to molecularly dissect mesothelioma tumor pathways by mean of microarray technologies in order to identify new tumor biomarkers, that could be used as early diagnostic markers and possibly as specific molecular therapeutic targets. We performed Affymetrix U133A plus 2.0 microarray analysis comparing 9 human pleural mesotheliomas with 4 normal pleural specimen. Stringent statistical feature selection detected a set of differentially expressed genes that were further evaluated to identify potential biomarkers to be used in early diagnostics. Selected genes were confirmed by RT-PCR. As reported by other mesothelioma profiling studies, most of genes are involved in G2/M transition. Our list contains several genes previously described as prognostic classifier. Furtherm

ORGANISM(S): Homo sapiens

SUBMITTER: Raffaele Calogero 

PROVIDER: E-GEOD-12345 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress