A library of yeast transcription factor motifs

ABSTRACT: The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 distinct structural classes. One-third of the binding specificities have not been previously reported. Several binding sequences have striking genomic distributions relative to transcription start sites, supporting their biological relevance and suggesting a role in promoter architecture. Among these are Rsc3 binding sequences, containing the core CGCG, which are found preferentially ~100 bp upstream of transcription start sites. Mutation of RSC3 results in a dramatic increase in nucleosome occu

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Lourdes Pena-Castillo 

PROVIDER: E-GEOD-12349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress