Analysis of MYC in murine lymphoma cell lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lars Bullinger
PROVIDER: E-GEOD-12400 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
Sander Sandrine S Bullinger Lars L Klapproth Kay K Fiedler Katja K Kestler Hans A HA Barth Thomas F E TF Möller Peter P Stilgenbauer Stephan S Pollack Jonathan R JR Wirth Thomas T
Blood 20080819 10
The MYC oncogene, which is commonly mutated/amplified in tumors, represents an important regulator of cell growth because of its ability to induce both proliferation and apoptosis. Recent evidence links MYC to altered miRNA expression, thereby suggesting that MYC-regulated miRNAs might contribute to tumorigenesis. To further analyze the impact of MYC-regulated miRNAs, we investigated a murine lymphoma model harboring the MYC transgene in a Tet-off system to control its expression. Microarray-bas ...[more]
Similar Datasets
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