Transcription profiling of human serous ovarian carcinomas reveals SE2Fs mediate a fundamental cell cycle deregulation in high-grade serous ovarian carcinomas

ABSTRACT: Several studies described a role for the E2F/Rb pathway in ovarian serous carcinomas (SCAs). Since E2F/Rb pathway deregulation is a general hallmark of human cancer, it remains unclear whether this deregulation is of particular importance in SCAs or whether it reflects a common oncologic feature. Here, we attempted to clarify this issue by the examination of microarray expression profiles of SCAs (10 SCA1s, 15 SCA3s) and particularly by the comparison with another, less malignant, ovarian cancer type, serous borderline tumours (13 SBTs). Results were further validated by quantitative RT-PCR, both on the microarray samples and an independent panel. In addition, TP53 mutation analysis was performed. This integrated analysis revealed a significant increase in the expression of the transcrip

ORGANISM(S): Homo sapiens

SUBMITTER: Jan Oosting 

PROVIDER: E-GEOD-12471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress