Gene expression profiles regulated by Tead2 mutants, Yap, and cell density in NIH3T3 cells

ABSTRACT: Regulation of organ size is important for development and tissue homeostasis. In Drosophila, Hippo signaling controls organ size by regulating the activity of a TEAD transcription factor, Scalloped, through modulation of its coactivator protein Yki. The role of mammalian Tead proteins in growth regulation, however, remains unknown. Here we examined the role of mouse Tead proteins in growth regulation. In NIH3T3 cells, cell density and Hippo signaling regulated the activity of Tead proteins by modulating nuclear localization of a Yki homologue, Yap, and the resulting change in Tead activity altered cell proliferation. Tead2-VP16 mimicked Yap overexpression, including increased cell proliferation, reduced cell death, promotion of EMT, lack of cell contact inhibition, and promotion o

ORGANISM(S): Mus musculus

SUBMITTER: Mitsunori Ota 

PROVIDER: E-GEOD-12498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress