Sessile serrated adenomas and conventional adenomas of the colon

ABSTRACT: Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated adenomas, hyperplastic polyps and tubular adenomas. Gene expression analysis demonstrated molecular differences between polyp types. Further studies using QRT-PCR on Cathepsin E demonstrated a significantly (p< 0.05) higher expression in sessile serrated adenomas as compared to both other polyp types. Trefoil Factor 1, showed the same trend of expression for sessile serrated adenomas as compared to hyperplastic polyps, and was significantly higher in both polyps compared to tubular adenomas. Imm

ORGANISM(S): Homo sapiens

SUBMITTER: maria caruso 

PROVIDER: E-GEOD-12514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress