Transcription profiling of human peripheral lymphocytes after exposure to cigarette smoke condensate in vitro

ABSTRACT: Little is known about alteration of the global gene expression by cigarette smoke (CS) and few biomarkers for smoking-related harm are available. We used Affymetrix HG-U133A GeneChips to measure the transcriptomes in eight cultured lymphocyte samples exposed to cigarette smoke condensate (CSC) in vitro . The in vitro exposure of lymphocytes to CSC significantly changed expression levels of 2,266 genes many of which biologically interacted. They included genes encoding for xenobiotic metabolism and oxidative stress-response (e.g. Nrf2 and AhR signaling pathways), inflammation/immune response (e.g. cytokines), apoptosis, cell cycle and tumorigenesis. However, the magnitude of expression responses for some genes showed high inter-individual variability. Experiment Overall Design: The goals of

ORGANISM(S): Homo sapiens

SUBMITTER: Jinguo Chen 

PROVIDER: E-GEOD-12586 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress