CMV infection induces a rapid and sustained change in the expression of Natural Killer Cell Receptors on CD8+ T Cells

ABSTRACT: The CD8+ T cell compartment of human cytomegalovirus (CMV) seropositive individuals characteristically contains a high proportion of cells that expresses Natural Killer Cell Receptors (NKR) which may contribute to the surveillance of virus-infected cells. To test if this enhanced expression is a direct and immediate result of CMV infection we used DNA microarrays to analyse putative changes in RNA-expression level of 39 NKRs in CMV-specific CD8+ T cells of renal transplant recipients experiencing primary CMV infection. Already in the acute phase of infection 29 NKRs were induced of which 19 remained high 1 year after cessation of viral replication. Activating and inhibitory NKRs were induced to a similar extent. Detailed longitudinal flowcytometric analyses confirmed NKR changes at the pro

ORGANISM(S): Homo sapiens

SUBMITTER: Amber van Stijn 

PROVIDER: E-GEOD-12589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress