Development and Diversification of Retinal Amacrine Interneurons at Single Cell Resolution

ABSTRACT: The vertebrate retina uses diverse neuronal cell types arrayed into complex neural circuits to extract, process and relay information from the visual scene to the higher order processing centers of the brain. Amacrine cells, a diverse class of inhibitory interneurons, are thought to mediate the majority of the processing of the visual signal that occurs within the retina. Despite morphological characterization, the number of known molecular markers of amacrine cell types is still much smaller than the 26 morphological types that have been identified. Furthermore, it is not known how this diversity arises during development. Here, we have combined in vivo genetic labeling and single cell genome-wide expression profiling to: 1) Identify specific molecular types of amacrine cells; 2) Demon

ORGANISM(S): Mus musculus

SUBMITTER: jeffrey trimarchi 

PROVIDER: E-GEOD-12601 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress