Transcription profilign of pig corneal and conjunctival keratinocyte clones

ABSTRACT: Integrity of the cornea, the most anterior part of the eye is indispensable for vision. 45 million individuals are bilaterally blind and another 135 millions have severely impaired vision in both eyes because of loss of corneal transparency; treatments range from local medications to corneal transplants and more recently to stem cell therapy. The corneal epithelium is a squamous epithelium that is constantly renewing with a vertical turnover of seven to fourteen days in many mammals3. Identification of slow cycling cells (label-retaining cells or LRCs) in the limbus of the mouse has led to the notion that the limbus is the niche for the stem cells responsible for the long-term renewal of the cornea4; hence, the corneal epithelium is supposedly renewed by cells generated at and migrating fr

ORGANISM(S): Sus scrofa

SUBMITTER: Sylvain Pradervand 

PROVIDER: E-GEOD-12604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress