HLA ligand profiles of primary renal cell carcinoma maintained in metastases.sue

ABSTRACT: In recent years, several approaches have been taken in the peptide-based immunotherapy of metastatic renal cell carcinoma (RCC), although little is known about HLA presentation on metastases compared to primary tumor and normal tissue of RCC. In this study we compared primary tumor, normal tissue and metastases with the aim of identifying similarities and differences between these tissues. We performed this comparison for two RCC patients on the level of the HLA ligandome using mass spectrometry and for three patients on the level of the transcriptome using oligonucleotide microarrays. The quantitative results show that primary tumor is more similar to metastasis than to normal tissue, both on the level of HLA ligand presentation and mRNA. We were able to characterize a total of 142 peptid

ORGANISM(S): Homo sapiens

SUBMITTER: Andreas Weinzierl 

PROVIDER: E-GEOD-12606 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress