Analysis of the CcpA regulon in Staphylococcus aureus

ABSTRACT: Background The catabolite control protein A (CcpA) is a member of the LacI/GalR family of transcriptional regulators controlling carbon-metabolism pathways in low-GC Gram positive bacteria. It functions as a catabolite repressor or activator, allowing the bacteria to utilize the preferred carbon source over secondary carbon sources. This study is the first CcpA-dependent transcriptome and proteome analysis in S. aureus wild type and ccpA-deleted mutant, focussing on short-time effects of glucose under stable pH conditions. Results The addition of glucose to exponentially growing S. aureus increased enzymes of glycolytic pathway, indicating a higher glycolytic activity, while proteins required for the complete oxidation in the TCA cycle were repressed via CcpA. Phosphotransacetylase and ac

ORGANISM(S): Staphylococcus aureus subsp. aureus str. Newman

SUBMITTER: Kati Seidl 

PROVIDER: E-GEOD-12614 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress