Transcription profiling of human metastatic melanoma biopsies - non-supervised hierarchical clustering of gene expression data

ABSTRACT: Despite the frequent detection of circulating tumor antigen-specific T cells, either spontaneously or following active immunization or adoptive transfer, immune-mediated cancer regression occurs only in the minority of patients. One theoretical rate-limiting step is whether effector T cells successfully migrate into metastatic tumor sites. Affymetrix gene expression profiling performed on a series of metastatic melanoma biopsies revealed a major segregation of samples based on the presence or absence of T cell-associated transcripts. The presence of lymphocytes correlated with the expression of defined chemokine genes. A subset of 6 chemokines (CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10) was confirmed by protein array and/or quantitative RT-PCR to be preferentially expressed in tumors t

ORGANISM(S): Homo sapiens

SUBMITTER: yuanyuan zha 

PROVIDER: E-GEOD-12627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress