Chip-Seq of mouse Ago-1 and TRIM32-bound small RNAs from E14.5 brain.

ABSTRACT: In the mouse neocortex, neural progenitor cells generate neurons through repeated rounds of asymmetric cell division. How distinct fates are established in their daughter cells is unclear. We show here that the TRIM-NHL protein TRIM32 segregates asymmetrically during progenitor division and induces neuronal differentiation in one of the two daughter cells. TRIM32 is highly expressed in differentiating neurons. In both horizontally and vertically dividing progenitor cells, TRIM32 distribution becomes polarized in mitosis so that the protein is enriched in one of the two daughter cells. While TRIM32 overexpression induces cell cycle exit and neuronal differentiation, TRIM32 RNAi causes both daughter cells to proliferate and prevents the initiation of a neuronal differentiation program . TRIM

ORGANISM(S): Mus musculus

SUBMITTER: Eugene Berezikov 

PROVIDER: E-GEOD-12633 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress