Listeria monocytogenes SOS response determined after mitomycin C exposure

ABSTRACT: The SOS response is a conserved pathway that is activated under certain stress conditions and is regulated by the repressor LexA and the activator RecA. The food-borne pathogen Listeria monocytogenes contains RecA and LexA homologs, but their roles in Listeria have not been established. In this study, we identified the SOS regulon in L. monocytogenes by comparing the transcription profiles of the wild-type strain and the ΔrecA mutant strain after exposure to the DNA damaging agent mitomycinC (MMC). The SOS response is an inducible pathway involved in DNA repair, restart of stalled replication forks, and in induction of genetic variation in stressed and stationary phase cells. It is regulated by LexA and RecA. LexA is an autoregulatory repressor which binds to a consensus sequence in the p

ORGANISM(S): Listeria monocytogenes EGD-e

SUBMITTER: Stijn van der Veen 

PROVIDER: E-GEOD-12634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress