Virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages

ABSTRACT: The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen, whose virulence requires proliferation inside host cells, including macrophages. Although some Francisella determinants of intracellular growth have been identified, much remains to be understood about the pathogenesis of this organism. In particular, how Francisella responds to its intracellular environment could provide clues about its intracellular biology and reveal pathogenic determinants based on their intracellular expression profiles. Here we have performed a global transcriptional profiling of the highly virulent F. tularensis subsp. tularensis Schu S4 strain during its intracellular cycle within primary murine macrophages. Phagocytosed bacteria rapidly responded to their intracellular

ORGANISM(S): Francisella tularensis subsp. tularensis SCHU S4

SUBMITTER: Stephen Porcella 

PROVIDER: E-GEOD-12663 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress