Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human lung adneocarcinomas - discovery of somatic mutations in lung adenocarcinomas

ABSTRACT: This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are likely to play a role in carcinogenesis. The observed mutational profiles correlate with clinical features, smoking status, and DNA repair defects. These results are complemented by data integration including SNP array data and gene expression array data (deposited here). Our findings shed further light on several key signaling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment. Experiment Overall Design: A subset of 75 RNAs from a corresponding set of 188 lung adenocarcinomas DNAs were resequenced across 623 genes.

ORGANISM(S): Homo sapiens

SUBMITTER: Rekha Meyer 

PROVIDER: E-GEOD-12667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Somatic mutations affect key pathways in lung adenocarcinoma.

Ding Li L   Getz Gad G   Wheeler David A DA   Mardis Elaine R ER   McLellan Michael D MD   Cibulskis Kristian K   Sougnez Carrie C   Greulich Heidi H   Muzny Donna M DM   Morgan Margaret B MB   Fulton Lucinda L   Fulton Robert S RS   Zhang Qunyuan Q   Wendl Michael C MC   Lawrence Michael S MS   Larson David E DE   Chen Ken K   Dooling David J DJ   Sabo Aniko A   Hawes Alicia C AC   Shen Hua H   Jhangiani Shalini N SN   Lewis Lora R LR   Hall Otis O   Zhu Yiming Y   Mathew Tittu T   Ren Yanru Y   Yao Jiqiang J   Scherer Steven E SE   Clerc Kerstin K   Metcalf Ginger A GA   Ng Brian B   Milosavljevic Aleksandar A   Gonzalez-Garay Manuel L ML   Osborne John R JR   Meyer Rick R   Shi Xiaoqi X   Tang Yuzhu Y   Koboldt Daniel C DC   Lin Ling L   Abbott Rachel R   Miner Tracie L TL   Pohl Craig C   Fewell Ginger G   Haipek Carrie C   Schmidt Heather H   Dunford-Shore Brian H BH   Kraja Aldi A   Crosby Seth D SD   Sawyer Christopher S CS   Vickery Tammi T   Sander Sacha S   Robinson Jody J   Winckler Wendy W   Baldwin Jennifer J   Chirieac Lucian R LR   Dutt Amit A   Fennell Tim T   Hanna Megan M   Johnson Bruce E BE   Onofrio Robert C RC   Thomas Roman K RK   Tonon Giovanni G   Weir Barbara A BA   Zhao Xiaojun X   Ziaugra Liuda L   Zody Michael C MC   Giordano Thomas T   Orringer Mark B MB   Roth Jack A JA   Spitz Margaret R MR   Wistuba Ignacio I II   Ozenberger Bradley B   Good Peter J PJ   Chang Andrew C AC   Beer David G DG   Watson Mark A MA   Ladanyi Marc M   Broderick Stephen S   Yoshizawa Akihiko A   Travis William D WD   Pao William W   Province Michael A MA   Weinstock George M GM   Varmus Harold E HE   Gabriel Stacey B SB   Lander Eric S ES   Gibbs Richard A RA   Meyerson Matthew M   Wilson Richard K RK  

Nature 20081001 7216

Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus ar  ...[more]

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