Transcription profiling of mouse p53-null with 3 p53/Pten double-null murine NSC

ABSTRACT: Glioblastoma (GBM) is a highly lethal brain tumor presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely as high-grade disease that typically harbors EGFR, PTEN and Ink4a/Arf mutations, and the secondary GBM subtype evolves from the slow progression of low-grade disease that classically possesses PDGF and p53 events1. Here, we show that concomitant CNS-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with striking clinical, pathological and molecular resemblance to primary GBM in humans. This genetic observation prompted p53 and PTEN mutational analysis in human primary GBM, demonstrating unexpectedly frequent inactivating mutations of p53

ORGANISM(S): Mus musculus

SUBMITTER: Hongwu Zheng 

PROVIDER: E-GEOD-12694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress