Experimental Malaria Infection Triggers Early Expansion of Natural Killer Cells - NK cell response

ABSTRACT: In order to gain a better understanding of gene expression during early malaria infection, we conducted microarray analysis of early blood responses in mice infected with erythrocytic stage Plasmodium chabaudi. Immediately following infection, we observed coordinated and sequential waves of immune responses, with interferon-associated gene transcripts dominating by 16 hours post-infection, followed by strong increases in natural killer (NK) cell-associated and MHC class I-related transcripts by 32 hours post-infection. We hypothesized that the observed elevation in NK cell-associated transcripts could be the result of a dramatic increase in the proportion of NK cells in the blood during infection, which we confirmed by flow cytometry. Subsequent microarray analysis of NK cells isolated

ORGANISM(S): Mus musculus

SUBMITTER: Joseph DeRisi 

PROVIDER: E-GEOD-12727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress