Transcription profiling of human chronic lymphocytic leukemia patients expressing high or low levels of ZAP70 mRNA

ABSTRACT: Comparison of Chronic Lymphocytic Leukemia patients expressing high or low levels of ZAP70 mRNA: prognostic factors and interaction with the microenvironment. Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia (CLL), but mechanisms by which its higher expression leads to a poor outcome remain to be fully explained. In an attempt to unveil unfavorable cellular properties linked to high ZAP70 expression, we used gene expression profiling to identify genes associated with disparities in B-cells from CLL patients expressing high versus low ZAP70 mRNA, measured by quantitative real-time PCR. Experiment Overall Design: Two groups of seven CLL patients were compared, selected on the basis of either high or low ZAP70 mRNA expression. Total R

ORGANISM(S): Homo sapiens

SUBMITTER: Basile Stamatopoulos 

PROVIDER: E-GEOD-12734 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress