Chromosome 11q and its association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer

ABSTRACT: Background: The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breast cancer patients. Overexpression of cyclin D1 protein however, confers tamoxifen resistance but not a tamoxifen induced adverse effect. Potentially, co-amplification of an additional 11q13 gene, with a resulting protein overexpression, is required to cause an agonistic effect. Moreover, during 11q13 amplification a deletion of the distal 11q region has been described. In order to assess the potential impact of the deletion we have examined a selected marker for this event. Methods: Array CGH an

ORGANISM(S): Homo sapiens

SUBMITTER: Åke Borg 

PROVIDER: E-GEOD-12759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress