Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human MCF10A cells reveal changes upon expression of activated versions of MEK1 and HRAS

ABSTRACT: MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot

ORGANISM(S): Homo sapiens

SUBMITTER: Tom Januario 

PROVIDER: E-GEOD-12764 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The basal-like subtype of breast cancer has an aggressive clinical behavior compared to that of the luminal subtype. We identified the microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as basal-like subtype-specific miRNAs and showed that expression of miR-221/222 decreased expression of epithelial-specific genes and increased expression of mesenchymal-specific genes, and increased cell migration and invasion in a manner characteristic of the epithelial-to-mesenchymal transition (EMT). The tr  ...[more]

PMID: 21673316

Publication: 1/2

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