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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Hematopoietic stem cell (HSC) expression alteration in an ADAR1 mouse model

ABSTRACT: Hematopoietic stem cells purified from +/+, +/- and -/- ADAR1 mice were compared with global gene expression analysis. Each sample was purified from one mouse.

ORGANISM(S): Mus musculus

SUBMITTER: Jun Lu

PROVIDER: E-GEOD-12772 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.

Hartner Jochen C JC Walkley Carl R CR Lu Jun J Orkin Stuart H SH

Nature immunology 20081207 1

The deaminase ADAR1 edits adenosines in nuclear transcripts of nervous tissue and is required in the fetal liver of the developing mouse embryo. Here we show by inducible gene disruption in mice that ADAR1 is essential for maintenance of both fetal and adult hematopoietic stem cells. Loss of ADAR1 in hematopoietic stem cells led to global upregulation of type I and II interferon-inducible transcripts and rapid apoptosis. Our findings identify ADAR1 as an essential regulator of hematopoietic stem ...[more]

PMID: 19060901

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Hematopoietic stem cell (HSC) expression alteration in an ADAR1 mouse model

Project description:Hematopoietic stem cells purified from +/+, +/- and -/- ADAR1 mice were compared with global gene expression analysis.

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HSC expression array

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2015-12-31 | E-GEOD-67496 | biostudies-arrayexpress

RNA-sequencing of splenic RNA from mice with compound mutations in ADAR1 and ZBP1

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2022-04-27 | E-MTAB-10953 | biostudies-arrayexpress

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