Paclitaxel resistant MDA-MB-231 Cells and resensitization with bexarotene treatment

ABSTRACT: Acquired drug resistance represents a major challenge in chemo-therapy treatment for various types of cancers. We have found that the retinoid X receptor–selective agonist bexarotene (LGD1069, Targretin) was efficacious in treating chemo-resistant cancer cells. The goal of this microarray study was to understand the mechanism of bexarotene’s role in overcoming acquired drug resistance using human breast cancer cells MDA-MB-231 as a model system and paclitaxel as model compound. After MDA-MB-231 cells were repeatedly treated with paclitaxel for 8 cycles with each cycle including a 3-day treatment with 30 nM paclitaxel and followed by a 7-day exposure to control medium, MDA cells resistant to paclitaxel were developed and their growth was no longer inhibited by paclitaxel treatment. T

ORGANISM(S): Homo sapiens

SUBMITTER: Wen Luo 

PROVIDER: E-GEOD-12791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress