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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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P53- repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation

ABSTRACT: There is a distinctive miRNA expression profile between early (young) and replicative senescence (old). We observed a cluster of miRNAs that were repressed upon senescence in both MRC-5 and WI-38 fibroblast cells. miRNAs profiling in young and senescence human emryonic fibroblasts (MRC-5 and WI-38)

ORGANISM(S): Homo sapiens

SUBMITTER: Giang Huong Nguyen

PROVIDER: E-GEOD-12821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

Brosh Ran R Shalgi Reut R Liran Atar A Landan Gilad G Korotayev Katya K Nguyen Giang Huong GH Enerly Espen E Johnsen Hilde H Buganim Yosef Y Solomon Hilla H Goldstein Ido I Madar Shalom S Goldfinger Naomi N Børresen-Dale Anne-Lise AL Ginsberg Doron D Harris Curtis C CC Pilpel Yitzhak Y Oren Moshe M Rotter Varda V

Molecular systems biology 20081125

Normal cell growth is governed by a complicated biological system, featuring multiple levels of control, often deregulated in cancers. The role of microRNAs (miRNAs) in the control of gene expression is now increasingly appreciated, yet their involvement in controlling cell proliferation is still not well understood. Here we investigated the mammalian cell proliferation control network consisting of transcriptional regulators, E2F and p53, their targets and a family of 15 miRNAs. Indicative of t ...[more]

PMID: 19034270

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p53- repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation

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p53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation

Project description:miRNA expression profiles of WI38 primary human fibroblasts with an active or inactive p53. Cells were compared under normal untreated conditions (young and proliferating cells), after DNA damage with Doxorubicin, and upon entry into replicative senescence. Keywords: miRNA, WI-38, p53, GSE56, Senescence, Doxorubicin, Cancer, DNA-damage, fibroblasts.

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