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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of humuan peripheral blood mononuclear cells stimulated with interleukin-12 and unstimulated controls

ABSTRACT: The cytokine interleukin-12 (IL-12) is known to play a central role in adaptive and innate immunity. We employed microarray analysis of IL-12 induced gene expression to provide further insights into its effects on immune response. Experiment Overall Design: PBMC's were isolated from 7 healthy NIH blood bank donors. For each donor, expression levels were measured for PBMCs stimulated with IL-12 and for unstimulated controls, using the Affymetrix Human Genome HG-U133A and HG-U133B GeneChips.

ORGANISM(S): Homo sapiens

SUBMITTER: Alan Berger

PROVIDER: E-GEOD-12839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.

Watford Wendy T WT Hissong Bruce D BD Durant Lydia R LR Yamane Hidehiro H Muul Linda M LM Kanno Yuka Y Tato Cristina M CM Ramos Haydeé L HL Berger Alan E AE Mielke Lisa L Pesu Marko M Solomon Benjamin B Frucht David M DM Paul William E WE Sher Alan A Jankovic Dragana D Tsichlis Philip N PN O'Shea John J JJ

The Journal of experimental medicine 20081110 12

Tpl2 (Tumor progression locus 2), also known as Cot/MAP3K8, is a hematopoietically expressed serine-threonine kinase. Tpl2 is known to have critical functions in innate immunity in regulating tumor necrosis factor-alpha, Toll-like receptor, and G protein-coupled receptor signaling; however, our understanding of its physiological role in T cells is limited. We investigated the potential roles of Tpl2 in T cells and found that it was induced by interleukin-12 in human and mouse T cells in a Stat4- ...[more]

PMID: 19001140

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Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes

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Discovery of a splicing regulator required for cell cycle progression

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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