Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Raja Jothi
PROVIDER: E-GEOD-12889 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cuddapah Suresh S Jothi Raja R Schones Dustin E DE Roh Tae-Young TY Cui Kairong K Zhao Keji K
Genome research 20081203 1
Insulators are DNA elements that prevent inappropriate interactions between the neighboring regions of the genome. They can be functionally classified as either enhancer blockers or domain barriers. CTCF (CCCTC-binding factor) is the only known major insulator-binding protein in the vertebrates and has been shown to bind many enhancer-blocking elements. However, it is not clear whether it plays a role in chromatin domain barriers between active and repressive domains. Here, we used ChIP-seq to m ...[more]