Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

BIOMARGIN study: Gene expression profiling in patients with a kidney transplantation

ABSTRACT: Microarrays were used to analyze the gene expression in peripheral blood and kidney allograft biopsies from patients with a kidney transplantation to get more insight in the molecular mechanisms underlying the different clinical phenotypes of kidney transplant rejection. 117 peripheral blood samples and 95 kidney allograft biopsies were used for genome-wide gene expression analysis. The updated Banff 2017 classification was used for diagnosis of the samples. Total RNA extracted from blood and biopsies was used to analyze mRNA expression via Affymetrix Human U133 Plus 2.0 arrays. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Maarten Naesens

PROVIDER: E-GEOD-129166 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: A multicentre, prospective study.

Van Loon Elisabet E Gazut Stéphane S Yazdani Saleh S Lerut Evelyne E de Loor Henriette H Coemans Maarten M Noël Laure-Hélène LH Thorrez Lieven L Van Lommel Leentje L Schuit Frans F Sprangers Ben B Kuypers Dirk D Essig Marie M Gwinner Wilfried W Anglicheau Dany D Marquet Pierre P Naesens Maarten M

EBioMedicine 20190801

<h4>Background</h4>Antibody-mediated rejection, a leading cause of renal allograft graft failure, is diagnosed by histological assessment of invasive allograft biopsies. Accurate non-invasive biomarkers are not available.<h4>Methods</h4>In the multicentre, prospective BIOMARGIN study, blood samples were prospectively collected at time of renal allograft biopsies between June 2011 and August 2016 and analyzed in three phases. The discovery and derivation phases of the study (N = 117 and N = 183 r ...[more]

PMID: 31378695

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Dataset Information

BIOMARGIN study: Gene expression profiling in patients with a kidney transplantation

Publications

Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: A multicentre, prospective study.

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