Transcriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures

ABSTRACT: Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial survival or death at supra-physiological temperatures. This study analyzed diverse facets of S. aureus heat-shock adjustment by recording global transcriptomic and metabolic responses of bacterial cultures shifted for 10 min from 37oC to a sub-lethal (43oC) or eventually lethal (48oC) temperature. A relevant metabolic model of the combined action of specific stress response mechanisms with more general, energy-regulating metabolic pathways in heat-shocked S. aureus was designed. While S. aureus cultures shifted to 43oC or left at 37oC showed marginal differences in growth and surviv

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Pierre Vaudaux 

PROVIDER: E-GEOD-12920 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress