Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kazuhiro Yamakawa
PROVIDER: E-GEOD-1294 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Amano Kenji K Sago Haruhiko H Uchikawa Chiharu C Suzuki Taishi T Kotliarova Svetlana E SE Nukina Nobuyuki N Epstein Charles J CJ Yamakawa Kazuhiro K
Human molecular genetics 20040511 13
Down syndrome (DS) is the most common chromosomally caused form of mental retardation and is caused by trisomy of chromosome 21. The over-expression of genes located on the trisomic region has been assumed to be responsible for the phenotypic abnormalities of DS, but this hypothesis has not been confirmed fully and the very existence of gene dosage effects has been called into question. We have therefore investigated global gene expression profiles in Ts1Cje, a mouse model for DS that displays l ...[more]