Transcription profiling of mouse testes from three strains, AKR/N, C57BL/6 and MRL/MpJ+/+

ABSTRACT: Cryptorchidism and scrotal heating result in abnormal spermatogenesis but the mechanism(s) proscribing this temperature sensitivity are unknown. It was previously reported that the AKR/N or MRL/MpJ-+/+ mouse testis is more heat resistant than the testis from the C57BL/6 strain. We have attempted to probe into the mechanism(s) involved in heat sensitivity by examining global gene expression profiles of normal and heat-treated testes from C57BL/6, AKR/N and MRL/MpJ-+/+ mice by microarray analysis. In the normal C57BL/6 testis, 415 and 416 transcripts were differentially expressed (at least two-fold higher or lower) when compared to the normal AKR/N and MRL/MpJ-+/+ testis, respectively. The AKR/N and MRL/MpJ-+/+ strains revealed 268 differentially expressed transcripts between them. Ther

ORGANISM(S): Mus musculus

SUBMITTER: Lizhong Yang 

PROVIDER: E-GEOD-12950 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress