Expression of Cdx2 or Gata3 in R1 mouse embryonic stem cells

ABSTRACT: To identify whether Cdx2 or Gata3 can activate trophoblast specific gene expression when expressed in R1 ES cells. To assess the dependency of Gata3 activity on Cdx2, Gata3 was also expressed in Cdx2-null ES cells. Keywords: gene expression a fusion construct of either Cdx2 or Gata3 and the tamoxifen responsive estrogen receptor ligand binding domain was expressed in R1 ES cells. Cell were induced with tamoxifen for 6 days to activate the transcription factor and cultured under trophoblast stem cell conditions

ORGANISM(S): Mus musculus

SUBMITTER: Brian Joseph Cox 

PROVIDER: E-GEOD-12986 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress