Early and long-standing rheumatoid arthritis: molecular signatures identified by gene expression profiling in synovium

ABSTRACT: At a given time, rheumatoid arthritis (RA) is a heterogeneous disease and its underlying molecular mechanisms is still poorly understood. Because previous microarrays studies have only focused on late RA stages, we aimed to compare the biological and molecular profiles in early and long-standing (LS) RA. Synovial biopsies obtained by arthroscopy were performed in 4 early untreated RA patients, 4 LS treated RA patients and 7 control patients. Extracted mRNA were linearly amplified and used for large-scale gene expression profiling by cDNA arrays. By gene ontology analysis, the different gene combinations obtained by comparison of early, LS RA and normal synovium were used to identify the biological processes, molecular functions and pathways involved at each stage. Three combinations of 71

ORGANISM(S): Homo sapiens

SUBMITTER: P Milliez 

PROVIDER: E-GEOD-13026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress