Human primary and secondary glioblastoma vs. non-neoplastic adult brain tissue

ABSTRACT: MicroRNAs (miRNAs) are small (21-25 nucleotide in length) non-coding RNA molecules that negatively regulate protein expression. They are linked to cancer development and maintenance. In this work, studying gene expression profiles of 340 mammalian miRNAs with DNA microarrays, we selected 10 miRNAs gene features able to distinguish primary from secondary glioblastoma type; furthermore we verified that miR-21 and miR-155 up-regulatation seems to characterize the glioblastoma tumour state since it was found up-regulated in all samples analyzed compared to adult brain noneoplastic tissue. Since miR-21 function in glioblastoma cells was addressed previously we concentrated our efforts on miR-155 function. We found that miR-155 levels were markedly elevated both in primary and secondary glioblas

ORGANISM(S): Homo sapiens

SUBMITTER: Oscar D'Urso 

PROVIDER: E-GEOD-13030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress