Transcription profiling of lung and liver from low and high dose Perfluorooctanoic Acid exposed fetuses

ABSTRACT: Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, cholesterol biosynthesis, steroid metabolism, bile acid biosynthesis, phospholipid metabolism, retinol metabolism, proteosome activation, and inflammation. These changes are consistent with activation of PPAR alpha. Non-PPAR alpha related changes were suggested as well. Experiment Overall Design: Experiment 1: High Dose: Thirty timed-pregnant CD-1 mice were orally dosed from gestation day 1-17 with either 0, 5, or 10 mg/kg/day PFOA in water. At term, fetal lung and liver were collected, total

ORGANISM(S): Mus musculus

SUBMITTER: Mitchell Rosen 

PROVIDER: E-GEOD-13044 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress