Human Insulin Resistance and Thiazolidinedione-Mediated Insulin Sensitization

ABSTRACT: Cellular and tissue defects associated with insulin resistance are coincident with transcriptional abnormalities and are improved after insulin sensitization with thiazolidinedione (TZD) PPAR? ligands. We transcriptionally profiled 364 biopsies gathered from 72 human subjects harvested before and after hyperinsulinemic-euglycemic clamp, at baseline and after three-month TZD treatment. Subjects range from insulin-sensitive to insulin-resistant. Insulin resistant subjects responded to TZD treatment with varied improvements in insulin sensitivity, thus they were ranked by their degree of TZD response to define responder and non-responder subgroups. Skeletal muscle biopsies were obtained from vastus lateralis before and after hyperinsulinemic-euglycemic clamp, at baseline and after three-month

ORGANISM(S): Homo sapiens

SUBMITTER: Gene Hsiao 

PROVIDER: E-GEOD-13070 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress