Genotyping of human neuroblastoma genes by combining genomic and expression microarrays SNP data set

ABSTRACT: Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. Subsequently, correlation of microarray data with survival and expression within rodent neuroblastomas were used to identify genes likely to be involved in the disease progression, and identified a significant excess of differentially expressed genes which correlated with survival within the minimally altered regions on 17q and 4p; Identif

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Stewart Jackson 

PROVIDER: E-GEOD-13137 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress