Rat medial prefrontal cortex gene expression following heroin self-administration, abstinence, and extinction

ABSTRACT: Several studies have investigated changes induced by drug exposure, but few reports have described changes that persist following relapse. In the present study, genome-wide analysis of gene expression was conducted in rats that expressed behavioral incubation of heroin-seeking and goal-directed behavior. The medial prefrontal cortex (mPFC) is important in mediating goal-directed behavior and also was the target of this analysis. Rats were trained to self-administer heroin (0.06 mg/0.2 ml infusion) during 3 hour daily sessions for 14 days. Following the self-administration period, rats were reintroduced to the self-administration chambers for a 90-minute extinction session. The extinction session occurred either 1 day or 14 days following the final self-administration session. Behavio

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kent Vrana 

PROVIDER: E-GEOD-13166 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress