Evaluation of gene expression profile in postmortem brain with Alzheimer´s disease-type neuropathological changes

ABSTRACT: Unravel the mechanisms underlying brain aging and Alzheimer´s disease (AD) has been difficult because of complexity of the networks that drive these aging-related changes. Analysis of the gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Gene microarray technology allows massively parallel analysis of most genes expressed in a tissue, and therefore is an important research tool that potentially can provide the investigative power needed to address the complexity of brain aging and neurodegenerative processes. One of the reasons that account for the resistance of AD pathogenesis to analysis is that clinically normal subjects may exhibit considerable AD pathology, blurring criteria for distinguishing subjects with nor

ORGANISM(S): Homo sapiens

SUBMITTER: Renato Puga 

PROVIDER: E-GEOD-13214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress