Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network

ABSTRACT: Significant insight about biological networks arises from the study of network motifs –overly abundant network subgraphs, but such wiring patterns do not specify when and how potential routes within a cellular network are used. To address this limitation, we introduce activity motifs, which capture patterns in the dynamic use of a network. Using this framework to analyze transcription in Saccharomyces cerevisiae metabolism, we find that cells use different timing activity motifs to optimize transcription timing in response to changing conditions: forward activation to produce metabolic compounds efficiently, backward shutoff to rapidly stop production of a detrimental product and synchronized activation for co-production of metabolites required for the same reaction Measuring protein abu

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Daphne Koller 

PROVIDER: E-GEOD-13219 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress