Transcription profiling of adult mouse Leydig cells exposed to DEHP

ABSTRACT: BACKGROUND: Phthalates are manmade industrial additives used mostly as plasticizers. In addition to their deleterious effects on male genital development, population studies have recently documented correlations between phthalates exposure and subtle impacts on reproductive tract development and on the metabolic syndrome in male adults. In mature rodents liver di-(2-ethylhexyl)-phthalate (DEHP) activates the peroxisome proliferators-activated receptor (PPARalpha), a member of the nuclear receptor (NR) superfamily. OBJECTIVES: Using a systems biology approach, we aimed at defining potential mechanisms underlying the impacts of DEHP on adult mouse liver and testis. METHODS: Thus, we performed a parallel analysis of transcript and metabolic profiles in the liver from adult mice exposed to v

ORGANISM(S): Mus musculus

SUBMITTER: Pascal GP Martin 

PROVIDER: E-GEOD-13240 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress