Transcription profiling of rat strains GotoKakizake) rats and 51 liver sample from WKY (WistarKyoto) rats feeded with normal diet (ND) and high fat diet (HFD) and sacrificed at 5 different ages: 4, 8, 12, 16, and 20 weeks - diabetes biomarker disease progression study in rat liver

ABSTRACT: The goals and objectives: To study Type 2 diabetes progression and the development of insulin resistance in two animal models with and without a high fat diet superimposed on these models. Background: Diabetes is a systemic metabolic imbalance involving multiple tissues/organs, and an early hallmark feature of this disease state is insulin resistance. Multifactorial interactions of genetics, prenatal environmental factors (fetal programming) and postnatal environmental factors (nutrition and activity) likely contribute to the diabetic phenotype.Animal models can serve as a valuable tool for studying diabetes disease progression and for identifying useful biomarkers of type 2 diabetes. Several inbred rodent models are available for diabetes related studies. The GK rat is an obvious choic

ORGANISM(S): Rattus norvegicus

SUBMITTER: Svetlana Ghimbovschi 

PROVIDER: E-GEOD-13270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress