Transcription profiling of human paediatric acute lymphoblastic leukaemia

ABSTRACT: We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double strand breaks in 74 paediatric ALL patients. We found an apoptosis-resistant response in 36% of patients and an apoptosis-sensitive response in the remaining 64% of leukaemias. Global gene expression profiling of 11 apoptosis-resistant and 11 apoptosis-sensitive ALLs revealed abnormal up-regulation of multiple pro-survival pathways in response to IR in apoptosis-resistant leukaemias and differential post-transcriptional activation of the PI3-Akt pathway was observed in representative resistant cases. It is possible that abnormal pro-survival responses to DNA damage provide one of the mechanisms of primary resistance in ALL . Experiment Overall Design: Twent

ORGANISM(S): Homo sapiens

SUBMITTER: Carmel McConville 

PROVIDER: E-GEOD-13280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress