Transcription profiling of human and rat uterine leiomyoma: identification of a dysregulated mTOR pathway

ABSTRACT: Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the primary cause of hysterectomy in the United States, accounting for up to 200,000 procedures annually, the etiology of leiomyoma remains largely unknown. Due to the lack of an effective medicinal therapy for these tumors, this disease continues to have a tremendous negative impact on women’s health. As a basis for understanding leiomyoma pathogenesis and identifying targets for pharmacotherapy, we conducted transcriptional profiling of leiomyoma and unaffected myometrium from humans and Eker rats, the best characterized preclinical model of leiomyoma. A global comparison of mRNA from leiomyoma versus myometrium in human and rat ident

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Jelinsky 

PROVIDER: E-GEOD-13319 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress