Mapping of copy-number alterations with massively parallel sequencing
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Derek Chiang
PROVIDER: E-GEOD-13373 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
High-resolution mapping of copy-number alterations with massively parallel sequencing.
Chiang Derek Y DY Getz Gad G Jaffe David B DB O'Kelly Michael J T MJ Zhao Xiaojun X Carter Scott L SL Russ Carsten C Nusbaum Chad C Meyerson Matthew M Lander Eric S ES
Nature methods 20081130 1
Cancer results from somatic alterations in key genes, including point mutations, copy-number alterations and structural rearrangements. A powerful way to discover cancer-causing genes is to identify genomic regions that show recurrent copy-number alterations (gains and losses) in tumor genomes. Recent advances in sequencing technologies suggest that massively parallel sequencing may provide a feasible alternative to DNA microarrays for detecting copy-number alterations. Here we present: (i) a st ...[more]
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