Transcription profiling of human primary human macrophages over the course of HIV-1 infection reveals HIV-1 activates macrophages independent of Toll-like receptors

ABSTRACT: Macrophages provide an interface between innate and adaptive immunity and are important long-lived reservoirs for Human Immunodeficiency Virus Type-1 (HIV-1). Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated by HIV-1 infection. To evaluate complex interrelated processes and to assemble an integrated view of activated signaling networks, a systems biology strategy was applied to genomic and proteomic responses by primary human macrophages over the course of HIV-1 infection. Macrophage responses, including cell cycle, calcium, apoptosis, mitogen-activated protein kinases (MAPK), and cytokines/chemokines, to HIV-1 were temporally regulated, in the absence of cell proliferation. In contrast, Toll-like

ORGANISM(S): Homo sapiens

SUBMITTER: Maureen Goodenow 

PROVIDER: E-GEOD-13395 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress