Profiling downregulation of the mevalonate pathway in Staphylococcus aureus

ABSTRACT: Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophosphate is absolutely required for the formation of cell wall peptidoglycan and other cell surface structures, while ubiquinones and menaquinones, both containing an essential prenyl moiety, are key electron carriers in respiratory energy generation. There is scant knowledge on the nature and regulation of bacterial isoprenoid pathways. In order to explore the cellular responses to perturbations in the mevalonate pathway, responsible for producing the isoprenoid precursor IPP in many Gram-positive ba

ORGANISM(S): Staphylococcus aureus RN4220

SUBMITTER: Carl Balibar 

PROVIDER: E-GEOD-13424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress