P53 regulates viral gene expression during infection with human cytomegalovirus

ABSTRACT: Human cytomegalovirus (HCMV) is a common cause of morbidity and mortality in immunocompromised and immunosuppressed individuals. During infection, HCMV is known to employ host transcription factors to facilitate viral gene expression. To further understand the previously observed delayed viral replication and protein expression in p53 knockout cells, we conducted microarray analyses on p53+/+ and p53-/- immortalized fibroblast cell lines. At 12 hpi, applying the significance criteria defined above, no genes showed a significant difference in any of the comparisons. At 24 hpi, we found 19 genes to be significantly different in the THF versus p53-/- comparison and 14 genes to be significantly different in the HFF versus p53-/- comparison. Eleven genes were shared between HFF and THF cells wh

ORGANISM(S): Human herpesvirus 5 strain Towne

SUBMITTER: John O'Dowd 

PROVIDER: E-GEOD-13437 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress