Virtual Karyotyping of Androgen Insensitive Prostate Cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Karla Alvarez
PROVIDER: E-GEOD-13439 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.
Sircar Kanishka K Yoshimoto Maisa M Monzon Federico A FA Koumakpayi Ismael H IH Katz Ruth L RL Khanna Abha A Alvarez Karla K Chen Guanyong G Darnel Andrew D AD Aprikian Armen G AG Saad Fred F Bismar Tarek A TA Squire Jeremy A JA
The Journal of pathology 20090801 4
PTEN haploinsufficiency is common in hormone-sensitive prostate cancer, though the incidence of genomic deletion and its downstream effects have not been elucidated in clinical samples of hormone refractory prostate cancer (HRPC). Progression to androgen independence is pivotal in prostate cancer and mediated largely by the androgen receptor (AR). Since this process is distinct from metastatic progression, we examined alterations of the PTEN gene in locally advanced recurrent, non-metastatic hum ...[more]
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