Transcription profiling of mouse cancer models by profiling saliva from tumor bearing mouse reveals induction of systemic disease-specific salivary biomarker profiles in mouse cancer models

ABSTRACT: Saliva (oral fluids) is an emerging biofluid poised for clinical diseases detection. Although the rationale for oral diseases applications (e.g. oral cancer) is clear, the rationale and relationship between systemic diseases and saliva biomarkers are unknown. In this study, we used mouse models of melanoma and non-small cell lung cancer and compared the transcriptome biomarker profiles of tumor-bearing mice to those of control mice. Microarray analysis showed that salivary transcriptomes were significantly altered in tumor-bearing mice vs. controls. Analysis of the transcriptomes in the mouse tumors, serum, salivary glands and saliva revealed that salivary biomarkers have multiple origins. Furthermore, we identified that the expression of two groups of significantly altered transcription f

ORGANISM(S): Mus musculus

SUBMITTER: David Wong 

PROVIDER: E-GEOD-13443 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress